Aspirin changes the metabolism of omega-6 fatty acids such that more anti-inflammatory compounds are produced. Aspirin also changes the metabolism of omega-3s such that even more anti-inflammatory compounds result. Fasting activates PPAR alpha which upregulates TFEB which results in new lysosomes in brain cells. Lysosomes eat the misfolded proteins in cells that cause amyloid-beta plaques and tau tangles. Aspirin appears to produce the same result without fasting. What if we fast and take aspirin? It stands to reason that aspirin may enhance the positive effects of fasting when it comes to brain health.