Aspirin changes the metabolism of omega-6 fatty acids such that more anti-inflammatory compounds are produced. Aspirin also changes the metabolism of omega-3s such that even more anti-inflammatory compounds result. Fasting activates PPAR alpha which upregulates TFEB which results in new lysosomes in brain cells. Lysosomes eat the misfolded proteins in cells that cause amyloid-beta plaques and tau tangles. Aspirin appears to produce the same result without fasting. What if we fast and take aspirin? It stands to reason that aspirin may enhance the positive effects of fasting when it comes to brain health.
The oil you drizzle on your salad or use to cook foods can have a profound effect on inflammation and in some cases specifically on brain inflammation.
Trans fats: Also called trans fatty-acids. Strongly correlated with systemic inflammation. Years of research has led to policy changes that have banned and/or phased out trans fats in an increasing number of markets.
- Inflammatory Markers Are Positively Associated with Serum trans–Fatty Acids in an Adult American Population
Olive Oil: Extra Virgin Olive Oil (EVOO). Use this at every opportunity. This is probably a large reason the Mediterranean Diet has been shown to protect against Alzheimer’s.
Temple University in the U.S. found the following about EVOO:
- EVOO reduced inflammation in the brain
- EVOO improved Alzheimer’s related behavioral deficits
- EVOO increased levels of synaptophysin, a protein found in healthy synpases
- EVOO reduced the levels and deposition of insoluble Aβ peptide
- EVOO lowered the amounts of phosphorylated tau protein
- EVOO activated cell autophagy
EVOO also contains omega-3 fatty acids shown to be neuroprotective:
Canola Oil: May contribute to Alzheimer’s.
- The mouseheimer’s study comparing memory […]
Omega-3 fatty acids are the basis of compounds that regulate inflammation, protect neurons, and promote neurite growth. Omega-6 fatty acids promote inflammation before they eventually get around to regulating inflammation.
Known primarily as the beneficial component of fish oil, Omega-3 polyunsaturated fatty acids (PUFAs) come in different varieties and sources. I don’t know about the stuffed shirts, but I like to say “poof-a.” I will probably work poof-a into conversation a number of times this week. Anywho, the PUFAs we call omega-3 have shown a lot of promise for neuroprotection, which we will look at in future articles. Here and now, we try to better understand something we’ve been hearing about for years.
Let’s Talk About Fat
Triglycerides. Our body fat is made of triglycerides. Triglycerides are also found floating in our blood. Triglycerides are made from a backbone of glycerol (also called glycerin) and 3 to 4 fatty acids. Glycerol is a colorless, odorless, sweet, and non-toxic liquid. Fatty acids are where all the variety comes in.
Fatty acids are usually 16, 18, or 20 carbon atoms long and most importantly fatty acids are either saturated or unsaturated.
Saturated. Imagine 16 people (carbon atoms really) holding hands as a chain. Each person is touching the person next to them only once (hand in hand). Each person in this chain is […]